ea0070oc1.2 | Adrenal and Cardiovascular Endocrinology | ECE2020
Merke Deborah
, Mallappa Ashwini
, Arlt Wiebke
, de la Perriere Aude Brac
, Hirschberg Linden Angelica
, Juul Anders
, Newell-Price John
, Perry Colin
, Prete Alessandro
, Rees Aled
, Reisch Nicole
, Stikkelbroeck Nike
, Touraine Phillippe
, Matlby Kerry
, Treasure Peter
, Porter John
, Ross Richard
Background: Patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-OHD-CAH) have poor health outcomes due to failure of currently available glucocorticoid preparations to control adrenocorticotropic hormone-driven androgen excess. We investigated whether modified-release hydrocortisone (MR-HC), which mimics the physiological circadian cortisol rhythm, could improve androgen control.Methods: 122 patients with 21-OHD-CAH ...